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Dennis J Thiele Selected Research

Heat Shock Transcription Factors

12/2020Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1.
2/2016Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors.
12/2011Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases.
1/2010Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease.
4/2006A stress regulatory network for co-ordinated activation of proteasome expression mediated by yeast heat shock transcription factor.
2/2004Activation of the Saccharomyces cerevisiae heat shock transcription factor under glucose starvation conditions by Snf1 protein kinase.

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Dennis J Thiele Research Topics

Disease

10Neoplasms (Cancer)
12/2020 - 10/2002
9Infections
01/2022 - 02/2003
7Iron Deficiencies
01/2018 - 06/2008
4Huntington Disease (Huntington's Disease)
01/2021 - 01/2010
3Anemia
01/2019 - 11/2013
3Neurodegenerative Diseases (Neurodegenerative Disease)
01/2017 - 01/2010
3Starvation
06/2008 - 02/2004
3Inflammation (Inflammations)
04/2006 - 02/2003
2Neoplasm Metastasis (Metastasis)
12/2020 - 12/2014
2Communicable Diseases (Infectious Diseases)
08/2014 - 03/2011
1Prostatic Neoplasms (Prostate Cancer)
12/2020
1Fungal Meningitis
01/2020
1Meningitis
01/2020
1Metabolic Diseases (Metabolic Disease)
01/2019
1Malnutrition (Nutritional Deficiencies)
01/2018
1Inflammatory Breast Neoplasms
06/2015
1Meningoencephalitis
11/2014
1Hepatolenticular Degeneration (Wilson's Disease)
05/2014
1Thyroid Neoplasms (Thyroid Cancer)
05/2014
1Carcinogenesis
05/2014
1Melanoma (Melanoma, Malignant)
05/2014
1Liver Diseases (Liver Disease)
11/2013
1Acute Promyelocytic Leukemia
05/2013
1Mycoses (Diseases, Fungus)
02/2012
1Alzheimer Disease (Alzheimer's Disease)
12/2011
1Parkinson Disease (Parkinson's Disease)
12/2011
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
12/2011
1Iron Overload
03/2011
1Mitochondrial Diseases (Mitochondrial Disease)
06/2009
1Genomic Instability
06/2009
1Nutrition Disorders (Nutritional Disorders)
10/2008
1Prion Diseases (Transmissible Spongiform Encephalopathies)
05/2006

Drug/Important Bio-Agent (IBA)

12CopperIBA
01/2022 - 04/2004
11Proteins (Proteins, Gene)FDA Link
01/2021 - 02/2004
8IronIBA
01/2018 - 10/2008
6Heat Shock Transcription FactorsIBA
12/2020 - 02/2004
6Messenger RNA (mRNA)IBA
01/2018 - 06/2008
5Carrier Proteins (Binding Protein)IBA
01/2018 - 06/2008
3polyglutamineIBA
01/2021 - 01/2010
3Transcription Factors (Transcription Factor)IBA
12/2020 - 04/2005
2Indicators and Reagents (Reagents)IBA
12/2020 - 12/2019
2Trace Elements (Biometals)IBA
01/2019 - 07/2015
2IonophoresIBA
06/2015 - 08/2014
2Copper Transport ProteinsIBA
11/2014 - 04/2004
2DNA (Deoxyribonucleic Acid)IBA
10/2014 - 02/2004
2PrionsIBA
12/2011 - 05/2006
2Glucose (Dextrose)FDA LinkGeneric
06/2008 - 02/2004
1Mixed Function Oxygenases (Monooxygenases)IBA
01/2020
1Polysaccharides (Glycans)IBA
01/2020
1Proteasome Endopeptidase Complex (Proteasome)IBA
01/2018
1Antifungal AgentsIBA
10/2017
1HepcidinsIBA
10/2015
1Disulfiram (Antabuse)FDA Link
06/2015
1Reactive Oxygen Species (Oxygen Radicals)IBA
06/2015
1Anti-Infective Agents (Microbicides)IBA
08/2014
1Proto-Oncogene Proteins B-rafIBA
05/2014
1Mitogen-Activated Protein KinasesIBA
05/2014
1Phosphotransferases (Kinase)IBA
05/2014
1Chelating AgentsIBA
05/2014
1CarcinogensIBA
05/2013
1MetallothioneinIBA
03/2013
1SulfurIBA
06/2009
1Succinate Dehydrogenase (Fumarate Reductase)IBA
10/2008
1AMP-Activated Protein KinasesIBA
06/2008
1MetalsIBA
04/2005
1SNF1-related protein kinasesIBA
02/2004
1Protein Isoforms (Isoforms)IBA
02/2004
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
02/2003
1Heat-Shock Proteins (Heat-Shock Protein)IBA
02/2003
1Pharmaceutical PreparationsIBA
10/2002
1Cisplatin (Platino)FDA LinkGeneric
10/2002

Therapy/Procedure

2Therapeutics
12/2020 - 06/2015
1Drug Therapy (Chemotherapy)
12/2014
1Chelation Therapy (Therapy, Chelation)
05/2014